Rosuvastatin Calcium foda, mai hana HMG-CoA reductase mai ƙarfi, an wajabta shi sosai don rage yawan LDL cholesterol da rage haɗarin abubuwan da ke faruwa na zuciya da jijiyoyin jini. A matsayinsa na memba na magungunan statin, ya canza maganin dyslipidemia kuma an nuna shi don rage yawan abubuwan da ke faruwa na cututtukan zuciya a cikin marasa lafiya masu haɗari [1]. Duk da yake yana da amfani ga marasa lafiya da yawa, ba kowa ba ne zai iya ɗaukar wannan magani saboda yiwuwar haɗari da hulɗar juna. Wannan shafin yanar gizon zai bincika mutanen da ya kamata su guje wa Rosuvastatin Calcium Powder, tattaunawa game da contraindications, hulɗar magunguna, da yawan jama'a na musamman waɗanda ke buƙatar taka tsantsan.
Contraindications sune yanayin da ke sa shi rashin lafiya ga majiyyaci ya ɗauki wani magani na musamman. Don Rosuvastatin Calcium Powder, akwai takamaiman yanayi inda ba a ba da shawarar amfani da shi ba. Waɗannan abubuwan da aka hana su sun dogara ne akan karatun asibiti, sa ido bayan tallace-tallace, da kuma yardawar masana.
1. Ciwon Hanta mai Aiki: Marasa lafiya da ke fama da cutar hanta, gami da waɗanda ke da tsayin daka da ba a bayyana ba a cikin maganin transaminases, kada su ɗauka. Rosuvastatin Calcium foda. Hanta tana taka muhimmiyar rawa wajen daidaita statins, kuma yanayin hanta da aka rigaya zai iya ƙara haɗarin hanta.
2. Ciki da shayarwa: Rosuvastatin an hana shi yayin daukar ciki saboda yuwuwar cutar da tayin. Abubuwan da ake samu na Cholesterol da cholesterol suna da mahimmanci don haɓaka tayin, kuma hana haɗarsu na iya haifar da rashin daidaituwa na haihuwa. Hakanan, ba a ba da shawarar lokacin shayarwa ba saboda yana iya shiga cikin nono[3].
3. Rashin hankali: Marasa lafiya da sanannen hauhawar jini ga Rosuvastatin ko duk wani abin da ke cikin sa yakamata su guji amfani da shi. Abubuwan rashin lafiyar na iya kamawa daga raƙuman fata mai laushi zuwa anaphylaxis mai tsanani.
4. Mummunan Rashin Lafiya: A cikin marasa lafiya da ke da nakasa mai tsanani (creatinine clearance <30 ml/min), an hana yin amfani da Rosuvastatin Calcium Powder, musamman a mafi girma allurai. Rashin aikin koda zai iya haifar da ƙara yawan ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar cuta [4].
5. Yin amfani da Cyclosporine na lokaci-lokaci: Haɗin Rosuvastatin da cyclosporine an hana shi saboda babban haɓakar bayyanar Rosuvastatin, wanda zai iya haɓaka haɗarin myopathy da rhabdomyolysis [5].
Fahimtar waɗannan contraindications yana da mahimmanci ga masu ba da lafiya da marasa lafiya don tabbatar da aminci da dacewa da amfanin Rosuvastatin Calcium Powder.
Hanyoyin hulɗar ƙwayoyi na iya tasiri sosai ga aminci da ingancin magunguna. Rosuvastatin Calcium foda ba banda, saboda yana iya yin hulɗa tare da wasu magunguna daban-daban, wanda zai iya haifar da mummunan tasiri. Waɗannan hulɗar na iya faruwa ta hanyoyi daban-daban, gami da sauye-sauye a cikin ƙwayoyin cuta, canje-canje a cikin ɗaurin furotin, ko tasiri akan masu jigilar magunguna.
1. Fibrates: Yin amfani da Rosuvastatin tare da fibrates, musamman gemfibrozil, na iya ƙara haɗarin myopathy. Ana tsammanin wannan hulɗar ta kasance saboda tasirin pharmacokinetic da pharmacodynamic. Marasa lafiya da ke buƙatar magungunan biyu ya kamata a kula da su sosai, kuma yakamata a yi la'akari da ƙananan allurai na Rosuvastatin[6].
2. Masu hana Protease: Wasu masu hana protease da ake amfani da su wajen maganin cutar kanjamau na iya ƙara yawan bayyanar Rosuvastatin. Misali, haɗewar Rosuvastatin tare da atazanavir/ritonavir ko lopinavir/ritonavir na iya haifar da ƙaruwa mai yawa a cikin ƙwayoyin plasma na Rosuvastatin. gyare-gyaren kashi da kulawa da hankali suna da mahimmanci lokacin da ake amfani da waɗannan magunguna tare[7].
3. Anticoagulants: Rosuvastatin na iya haɓaka tasirin anticoagulant na warfarin da sauran masu adawa da bitamin K. Marasa lafiya a duka magunguna ya kamata a kula da INR su a hankali, musamman lokacin farawa ko daidaita kashi na Rosuvastatin[8].
4. Niacin: Haɗin Rosuvastatin tare da niacin a allurai masu canza lipid (≥1 g / rana) yana da alaƙa da haɓakar haɗarin myopathy. Yayin da wannan haɗin zai iya ba da ƙarin fa'idodin rage yawan lipid, yana buƙatar yin la'akari da kulawa sosai[9].
5. Colchicine: Ko da yake ba a hana shi ba, yin amfani da Rosuvastatin da colchicine lokaci guda yana da alaƙa da keɓantattun lokuta na myopathy. Ya kamata a shawarci marasa lafiya su ba da rahoton duk wani ciwon tsoka da ba a bayyana ba, taushi, ko rauni[10].
Ma'aikatan kiwon lafiya ya kamata su gudanar da cikakken nazarin magani kafin rubutawa Rosuvastatin Calcium foda kuma la'akari da yuwuwar hulɗar tare da tsarin maganin majiyyaci na yanzu. A wasu lokuta, gyare-gyaren kashi ko madadin jiyya na iya zama dole don rage haɗarin illa.
Wasu jama'a, kamar mata masu juna biyu, masu shayarwa, da kuma daidaikun mutane masu nakasa hanta ko koda, na iya buƙatar kulawa ta musamman idan ana maganar amfani da magunguna. Amfani da Rosuvastatin Calcium Powder a cikin waɗannan al'ummomi yakamata a kimanta shi a hankali, yana auna fa'idodi da haɗarin.
1. Marasa lafiya Tsofaffi: Duk da yake shekarun da kansu ba abin da ya hana yin amfani da Rosuvastatin ba ne, tsofaffi marasa lafiya na iya zama masu saurin kamuwa da mummunan sakamako saboda canje-canje masu alaƙa da shekaru a cikin metabolism na miyagun ƙwayoyi da haɓaka yiwuwar kamuwa da cuta. Ƙananan matakan farawa na iya dacewa a cikin wannan yawan[4].
2. Marasa lafiya tare da Hypothyroidism: Rashin maganin hypothyroidism na iya haifar da marasa lafiya zuwa myopathy lokacin shan statins. Ya kamata a kimanta aikin thyroid kafin fara aikin Rosuvastatin, kuma yakamata a kula da hypothyroidism sosai[11].
3. Yawan Jama'ar Asiya: Nazarin ya nuna cewa marasa lafiya na Asiya na iya samun mafi yawan ƙwayar plasma na Rosuvastatin idan aka kwatanta da marasa lafiyar Caucasian. A sakamakon haka, ana ba da shawarar ƙananan allurai na farawa ga marasa lafiya na Asiya, kuma ya kamata a yi girman girman kashi a hankali[12].
4. Marasa lafiya tare da Tarihin Statin-Induced Myopathy: Mutanen da suka taɓa samun ciwon myopathy a baya tare da sauran statins na iya kasancewa cikin haɗari yayin shan Rosuvastatin. Za'a iya la'akari da dabarun rage yawan lipid ko ƙananan allurai tare da kulawa da hankali ga waɗannan marasa lafiya[13].
5. Marasa lafiya da ke fama da matsalar shan barasa: Yawan shan barasa na iya ƙara haɗarin haɗarin hanta. Ya kamata a shawarci marasa lafiya da tarihin shan barasa akan mahimmancin iyakance shan barasa kuma yana iya buƙatar ƙarin kulawa da aikin hanta akai-akai[14].
Rosuvastatin Calcium foda magani ne mai tasiri don sarrafa matakan cholesterol, amma bai dace da kowa ba. Fahimtar contraindications, yuwuwar hulɗar magunguna, da bukatun jama'a na musamman yana da mahimmanci don tabbatar da amincin haƙuri. Ma'aikatan kiwon lafiya dole ne su kimanta abubuwan haɗari na kowane majiyyaci, tarihin likita, da magunguna masu haɗaka kafin rubuta Rosuvastatin. Ya kamata a ilmantar da marasa lafiya game da haɗarin da ke tattare da su kuma a shawarce su da su ba da rahoton duk wani alamun da ba a saba gani ba cikin sauri. Kulawa na yau da kullun, gami da matakan lipid, gwajin aikin hanta, kuma a wasu lokuta, matakan creatine kinase, yana da mahimmanci don aminci da ingantaccen amfani da Rosuvastatin Calcium Powder. Koyaushe tuntuɓi mai ba da lafiya kafin farawa ko canza kowane tsarin magani.
Idan kuma kuna sha'awar wannan samfurin kuma kuna son ƙarin cikakkun bayanai na samfur, ko kuna son sanin wasu samfuran masu alaƙa, da fatan za a iya tuntuɓar su. iceyqiang@aliyun.com.
References:
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2. Russo MW, et al. Raunin hanta da ke haifar da ƙwayoyi tare da statins. Semin Hanta Dis. 2014;34 (2):205-214.
3. Gouveia A, et al. HMG-CoA reductase inhibitors da sakamakon ciki. Cutar Gynecol. 2004; 104 (6): 1227-1231.
4. Rosuvastatin [fakitin sakawa]. Wilmington, DE: AstraZeneca Pharmaceuticals LP; 2020.
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7. Aslangul E, et al. Rosuvastatin da pravastatin a cikin marasa lafiya marasa lafiya da suka kamu da cutar ta HIV-1 suna karɓar masu hana protease: gwaji bazuwar. AIDS. 2010;24 (1):77-83.
8. Jindal D, et al. Pharmacodynamic kimantawar warfarin da haɗin gwiwar rosuvastatin a cikin batutuwa masu lafiya. Eur J Clin Pharmacol. 2005;61 (9): 621-625.
9. Ƙungiyar Haɗin gwiwar HPS2-THRIVE. Sakamakon tsawaita-sakin niacin tare da laropiprant a cikin majinyata masu haɗari. N Engl J Med. 2014;371(3):203-212.
10. Tufan A, et al. Rhabdomyolysis a cikin marasa lafiya da aka bi da colchicine da atorvastatin. Ann Pharmacother. 2006;40 (7-8): 1466-1469.