Paroxetine, Zaɓaɓɓen mai hana mai hanawa na serotonin reuptake (SSRI), ya ba da hankali a cikin 'yan shekarun nan don yuwuwar amfani da shi wajen magance saurin inzali (PE). Wannan rashin aikin jima'i na yau da kullun yana shafar maza da yawa a duniya, yana haifar da damuwa da tasiri dangantaka. Duk da yake an wajabta shi da farko don baƙin ciki da damuwa, amfani da lakabin paroxetine don PE ya nuna sakamako mai ban sha'awa a cikin wasu binciken. Koyaya, kamar yadda yake tare da kowane magani, yana da mahimmanci don fahimtar ingancinsa, yuwuwar illolinsa, da wasu hanyoyi kafin la'akari da shi azaman zaɓin magani.
Tsarin aikin Paroxetine wajen magance fitar maniyyi da wuri yana da alaƙa da farko da tasirin sa akan matakan serotonin a cikin kwakwalwa. A matsayin SSRI, paroxetine yana ƙara yawan samuwar serotonin a cikin ɓangarorin synaptic ta hana sake dawowa. An yi imanin wannan karuwa a cikin serotonin yana da tasiri mai tasiri akan fitar da maniyyi.
Madaidaicin hanyar neurophysiological ta hanyar da paroxetine ke jinkirta fitar maniyyi ba a fahimta sosai ba. Duk da haka, masu bincike sun ba da shawarar cewa ƙara yawan matakan serotonin na iya rinjayar reflex na inzali ta hanyoyi da yawa:
1. Modulation na tsakiya serotonergic neurotransmission: Serotonin yana taka muhimmiyar rawa wajen daidaita aikin jima'i, gami da fitar maniyyi. Ta hanyar haɓaka matakan serotonin, paroxetine na iya taimakawa wajen hana reflex na inzali, yana haifar da jinkiri a cikin maniyyi.
2. Abubuwan da ke kewaye da su: Wasu nazarin sun nuna cewa SSRIs kamar paroxetine na iya samun sakamako na gefe akan tsarin genitourinary, wanda zai iya rinjayar ƙaddamarwar vas deferens, seminal vesicles, da prostate.
3. Rashin jin daɗi na masu karɓar 5-HT1A: Yin amfani da paroxetine na dogon lokaci na iya haifar da rashin jin daɗi na wasu masu karɓar serotonin, wanda zai iya taimakawa wajen haifar da jinkirin fitar da maniyyi.
4. Ƙara yawan nitric oxide synthesis: Akwai wasu shaidun da ke nuna cewa SSRIs na iya ƙara samar da nitric oxide, wanda zai iya taka rawa wajen jinkirta fitar maniyyi.
An nuna tasirin paroxetine a cikin kula da PE a cikin binciken asibiti da yawa. Wani bincike-bincike da aka buga a cikin Jarida na Asiya na Andrology ya gano cewa paroxetine ya ƙaru sosai lokacin jinkirin intravaginal ejaculatory latency (IELT) idan aka kwatanta da placebo. Binciken ya ba da rahoton cewa jiyya na yau da kullun tare da paroxetine ya haifar da haɓakar ninki 7.54 a cikin IELT.
Koyaya, yana da mahimmanci a lura cewa martani ga paroxetine na iya bambanta tsakanin mutane. Wasu mazan na iya samun ci gaba mai mahimmanci a cikin sarrafa maniyyi, yayin da wasu na iya ganin sakamako kaɗan. Bugu da ƙari, mafi kyawun sashi da tsawon lokacin jiyya don PE har yanzu batutuwa ne na ci gaba da bincike.
Hakanan yana da kyau a faɗi cewa sakamakon jinkirta inzali na paroxetine yana ɗaukar kwanaki da yawa zuwa makonni don bayyana. Wannan ya bambanta da jiyya da ake buƙata kamar maganin sa barci, wanda ke aiki da sauri. Sabili da haka, ana wajabta paroxetine gabaɗaya azaman magani na yau da kullun maimakon maganin buƙatu don PE.
Duk da yake paroxetine na iya zama tasiri ga maza da yawa tare da PE, yana da mahimmanci don tuntuɓar mai ba da lafiya kafin fara kowane sabon magani. Za su iya tantance halin da ake ciki na mutum ɗaya, tattauna fa'idodi da haɗari masu yuwuwa, kuma su tantance idan paroxetine zaɓin magani ne da ya dace a gare ku.
Yayin da paroxetine ya nuna inganci wajen magance saurin inzali, ba shine kawai zaɓin da ake samu ba. Akwai zaɓuɓɓuka da yawa, kama daga wasu magunguna zuwa dabarun ɗabi'a da saɓanin tunani. Fahimtar waɗannan hanyoyin zai iya taimakawa mutane da ma'aikatan kiwon lafiya su yanke shawara game da mafi dacewa hanyar magani.
1. Sauran SSRIs:
Paroxetine ba shine kawai SSRI da ake amfani dashi don PE ba. Sauran SSRIs da aka yi nazari don wannan dalili sun haɗa da:
- Sertraline
-Fluoxetine
- Citalopram
- Escitalopram
Waɗannan magunguna suna aiki daidai da paroxetine amma suna iya samun ɗan ɗan bambanta bayanan martaba ko ƙimar inganci. Wasu mazan na iya amsa mafi kyau ga SSRI ɗaya akan wani.
2. Dapoxetine:
Dapoxetine shine SSRI na gajeren lokaci wanda aka tsara musamman don maganin PE. An amince da shi don amfani akan buƙata a wasu ƙasashe, kodayake ba a cikin Amurka ba. Dapoxetine yana da fa'idar ɗauka kawai lokacin da ake buƙata, mai yuwuwar rage haɗarin illa masu alaƙa da amfani da SSRI yau da kullun.
3. Tramadol:
An yi nazarin wannan maganin ciwo na opioid don amfani da tambarin sa a cikin jiyya na PE. Yana iya aiki ta ƙara matakan serotonin da hana norepinephrine reuptake. Duk da haka, amfani da shi don PE yana da rikici saboda hadarin dogara da sauran abubuwan da ke tattare da opioids.
4. Masu hana PDE5:
Magunguna irin su sildenafil (Viagra), tadalafil (Cialis), da vardenafil (Levitra) ana amfani da su da farko don rashin aiki na mazauni amma kuma suna iya taimakawa tare da PE a wasu maza, musamman ma wadanda suka fuskanci matsalolin rashin ƙarfi.
5. Maganin ciwon daji:
Ana iya shafa man shafawa, feshi, ko goge masu ɗauke da maganin sa barci kamar lidocaine ko prilocaine akan azzakari don rage hankali da jinkirta fitar maniyyi. Ana samun waɗannan kan-da-counter a ƙasashe da yawa kuma ana iya amfani da su akan buƙata.
6. Dabarun ɗabi'a:
Hanyoyi da yawa waɗanda ba na magunguna ba na iya yin tasiri a sarrafa PE:
- Dabarar dainawa: Wannan ya haɗa da motsa jiki har zuwa lokacin da ake fitar da maniyyi, sannan a daina har sai sha'awar ta ragu.
- Dabarar matsi: kama da dabarar farawa, amma ya haɗa da matse kan azzakari a hankali don rage tashin hankali.
- Motsa jiki na ƙashin ƙashin ƙugu: Ƙarfafa tsokoki na ƙashin ƙashin ƙugu na iya taimakawa wajen inganta sarrafa maniyyi.
- Al'aura kafin jima'i: Wannan na iya taimakawa wajen jinkirta fitar maniyyi yayin jima'i.
7. Matsalolin tunani:
PE na iya samun abubuwan haɗin kai, kuma magance waɗannan na iya zama da fa'ida:
- Abin sani-hali-halakai na halaye-halaye-halaye: Wannan na iya taimakawa wajen magance damuwa, alamomin tunani, ko maganganun dangantakar da zasu iya ba da gudummawa ga pe.
- Hanyoyi masu hankali: Koyan mayar da hankali kan jin daɗin jiki ba tare da hukunci ba zai iya taimakawa wajen inganta aikin jima'i da kuma rage damuwa.
- Maganin ma'aurata: Wannan zai iya taimakawa wajen magance matsalolin dangantaka da inganta sadarwa game da matsalolin jima'i.
8. Hanyoyi masu haɗa kai:
Yawancin masu ba da kiwon lafiya suna ba da shawarar haɗuwa da hanyoyin magunguna da marasa magani don ingantaccen kulawar PE. Misali, yin amfani da maganin sa barci tare da dabarun ɗabi'a, ko haɗa SSRI tare da jiyya na tunani.
9. Maganin dabi'a:
Yayin da shaidar kimiyya ta iyakance, wasu maza suna ba da rahoton fa'idodi daga hanyoyin dabi'a kamar:
- Abubuwan da ke da sinadarin Zinc
- Ganyen Ayurvedic kamar Ashwagandha
- Acupuncture
Duk da haka, yana da mahimmanci a tunkari waɗannan tare da taka tsantsan kuma a tattauna amfani da su tare da mai ba da lafiya, saboda ko da magungunan halitta na iya samun illa ko mu'amala da wasu magunguna.
10. Magani masu tasowa:
Bincike a cikin maganin PE yana gudana, tare da sababbin hanyoyin bincike. Waɗannan sun haɗa da:
- allurar dafin botulinum
- Gyaran jijiya azzakari
- Sabbin hanyoyin magungunan da ake dasu don amfani akan buƙatu
Idan kuma kuna sha'awar wannan samfurin kuma kuna son ƙarin cikakkun bayanai na samfur, ko kuna son sanin wasu samfuran masu alaƙa, da fatan za a iya tuntuɓar su. iceyqiang@aliyun.com.
References:
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